脂联素调控脂质代谢的研究进展

doi:10.11843/j.issn.0366-6964.2018.12.003

摘要/Abstract

摘要：

脂联素（adiponectin，AdipoQ）是一种主要由脂肪组织分泌的脂肪细胞因子。近年来的研究表明，脂联素在调节动物脂质代谢中发挥重要的作用。脂联素与脂联素受体（AdipoR1和AdipoR2）C端结合后，脂联素受体N端再与信号接头蛋白（APPL1和CK2）结合，影响肝激酶（LKB1）或沉默信息调节因子1（SIRT1）的活性或表达，激活AMPK和PPARα等信号因子，促进脂肪酸氧化和抑制脂质合成，达到降脂的作用。目前，关于脂联素调节脂质代谢的研究主要集中于人和啮齿动物，并且相关的分子调控机制研究已取得了一定进展。本文就脂联素的发现、结构、组织分布、信号接头蛋白和其调节动物脂质代谢的机制进行综述，以期为深入探究该基因在调控脂质代谢的作用机制提供参考。

Abstract:

Adiponectin (AdipoQ) is an adipocytokine mainly secreted by adipose tissue. Recent studies have shown that adiponectin played an important role in regulating lipid metabolism in animals. Adiponectin firstly binds to C terminal of adiponectin receptors, namely AdipoR1 and AdipoR2, N terminal of adiponectin receptor is combined with signal adapter protein (APPL1 and CK2) subsequently, then affect the activity or expression of related kinases (LKB1 and SIRT1), finally activate AMPK and PPARα signaling factors to promote fatty acid oxidation and inhibit lipid synthesis, thereby exerting lipid-lowering effects. At present, the research on lipid metabolism regulated by adiponectin have focused on human and rodents, and some progress has been made in the study of related molecular regulation mechanisms. This article reviews the discovery, structure, tissue distribution, signal adapter proteins of adiponectin, as well as the mechanism of adiponectin regulating animal lipid metabolism in order to provide a partial reference for further exploring the role of this gene in the regulation of lipid metabolism.

中图分类号:

S811.3

唐妮, 王书瑶, 齐锦雯, 吴源冰, 李志琼. 脂联素调控脂质代谢的研究进展[J]. 畜牧兽医学报, 2018, 49(12): 2550-2557.

TANG Ni, WANG Shu-yao, QI Jin-wen, WU Yuan-bing, LI Zhi-qiong. Research Progress on Adiponectin Regulating Lipid Metabolism[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2018, 49(12): 2550-2557.

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